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KMID : 0861020080230010009
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Korea Journal of Herbology
2008 Volume.23 No. 1 p.9 ~ p.15
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Effects of Water Extracts from Lagocephalus wheeleri with Several Herbs on Hyperlipemia and Liver Damage Induced by Alcohol
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Seo Bu-Il
Park Ji-Ha
Choi Hong Sik
Kim Seung Mo
Goo Deok-Mo
Kim Mi-Ryeo
Park Jin-Hyun
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Abstract
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Objectives: This study was performed to investigate the effect of water extracts from Lagocephalus
wheeleri with several herbs(LW) on hyperlipemia and liver damage induced by alcohol.
Methods: Except for the normal group, we fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. We measured the serum component in rat’s blood, body weight and weight of liver.
Results: At first, we observed effects of LW on hyperlipemia induced by alcohol. LW group didn’t show
significant increase of total cholesterol in comparison with those of the control group. LW group didn’t
show significant increase of HDL(High-Density lipoprotein) cholesterol in comparison with those of the
control group. LW group showed significant decrease of triglyceride in comparison with those of the
control group. LW group showed significant increase of body weight in comparison with those of the
control group in 4weeks and 8weeks. LW group showed significant increase of liver weight in comparison with those of the control group. At second, we observed effects of LW on liver damage induced by alcohol. LW group showed
significant decrease of ALP, GOT, GPT and LDH in comparison with those of the control group.
Conclusions: Reviewing these experimental results, it appears that water extracts from Lagocephalus
wheeleri with several herbs have pharmaceutical efficacy on hyperlipidemia and liver damage induced by
alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical
efficacy of this.
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KEYWORD
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Lagocephalus wheeleri, hyperlipidemia, Liver damage, alcohol
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